Visual PDCPDC Design
Peptide–drug conjugates (PDCs) link a peptide (targeting or carrier) to a payload via a linker. Design choices affect stability, release, and efficacy. Visual PDC supports molecular weight, DPR, stability, and 3D structure for PDC design.
Peptide carrier and targeting
The peptide moiety can provide targeting (e.g. receptor-binding) or act as a carrier. Sequence affects stability, charge, and solubility. Use the Stability Calculator and PDC Molecular Weight to compare variants.
Stability Calculator →Linker and payload
The linker connects peptide to payload and can be cleavable (e.g. protease-sensitive) or non-cleavable. Drug-to-peptide ratio (DPR) and total molecular weight influence formulation and dosing. Use the DPR calculator to explore loading.
PDC Molecular Weight (DPR) →Stability and release
In vitro and in vivo stability depend on peptide sequence, linker chemistry, and payload. Stability prediction and release assays inform design. Export reports (PDF, CSV) for lab records and publication.
PDC Report Export →Using Visual PDC
Enter peptide and drug (SMILES) in PDC Molecular Weight (DPR) for total MW, charge, pI, logP. Use Stability Calculator for stability indices from the peptide moiety. View peptide–drug 3D in PDC 3D Structure, Payload Attachment Site, and Peptide-Drug Complex; export PDB, PNG, and reports via Export formats and PDC Report Export. Data sources: Data Sources (DrugBank, PDB, PubChem, UniProt).